Concentrations are increased in patients with pancreatic, gastric, and colon cancer as well as in some nonmalignant conditions. Haese et al presented preliminary results from a European multicenter study of PCA3. Tosoian et al evaluated the relationship between PCA3 and prostate biopsy results in men in a surveillance program.
Background A tumor marker is a substance such as a protein, antigen or hormone in the body that may indicate the presence of cancer. Monitoring with CA has not been shown to improve the management of patients with colorectal cancer. They stated that further analysis is necessary to assess the usefulness of PCA3 in combination with other biomarkers or in selected subsets of patients undergoing surveillance.
Carmignani et al a conducted a study to report the role of combined treatments, including cytoreductive surgery and perioperative regional chemotherapy, in patients with synchronous systemic and intraperitoneal dissemination of appendix cancer.
How do you know a real problem, situation, or opportunity will be studied? One antibody, having stable characteristics over the wide range of pH and salt concentrations found in urine and minimal cross-reactivity with other beta thymosins, was used to develop a competitive enzyme-linked immunosorbent assay ELISA.
At least one of the tumor markers was elevated in Elevated serum CA This is a moderate-strength recommendation based upon intermediate-quality evidence.
Measurement of CA levels and completion of pelvic ultrasonography both abdominal and transvaginal have been the two tests most thoroughly evaluated CA is produced by adenocarcinomas of the pancreas, stomach, gall-bladder, colon, ovary, and lung, and it is shed into the circulation.
For all other settings, comparators, and outcomes, there was insufficient evidence.
Implicit in this overview is the recognition by the researcher that both secondary data—document-based data, organizational material, library books, and journals—and primary data—empirical, qualitative, and quantitative data incorporated by a survey, experiment, and so on in a real-time fashion—was gathered to make the study comprehensive, fully researched, and as rigorous as a project must be within the scientific method of data planning, gathering, and analysis.
They stated that further evaluation of this marker is necessary before its use as an adjunct to cystoscopy for urothelial carcinoma of the bladder.
These investigators concluded that urinary cathepsin L is an independent predictor of bladder cancer presence and invasiveness in patients with a history of urothelial carcinoma of the bladder. Charts of patients were reviewed. Data suggest that currently available tests do not appear to be beneficial for screening low-risk, asymptomatic women because their sensitivity, specificity, positive predictive value, and negative predictive value have all been modest at best.
The authors concluded that an ELISA that is able to detect thymosin B15 at clinically relevant concentrations in urine from patients with prostate cancer has been established.
CA levels can also be elevated by cancers of the colon, stomach, kidney, lung, ovary, pancreas, uterus, and liver. Inhibin — One of two hormones designated inhibin-A and inhibin-B secreted by the gonads by Sertoli cells in the male and the granulosa cells in the female and inhibits the production of follicle-stimulating hormone FSH by the pituitary gland; Lactate Dehydrogenase LDH — Marker used to monitor treatment of testicular cancer; Mucin-1 MUC-1 — Carbohydrate antigen elevated in individuals with tumors of the breast, ovary, lung and prostate as well as other disorders; Napsin A — Protein used as a marker in the evaluation of lung cancer; Prealbumin — Marker of nutritional status and a sensitive indicator of protein synthesis.
Methods of detecting tumor markers include, but are not limited to: Provide an overview of the scope of the study in the chosen article by explaining data collection and where to find the data. While PSA does not allow distinction between benign prostate conditions and cancer, an elevated PSA level may indicate that other tests are necessary to determine whether cancer is present.
The detection of tumor markers may be used to determine a diagnosis or as an indicator of disease cancer progression.
Recruitment for large scale studies given the rare nature of mucinous appendiceal carcinoma would be challenging. What are its weaknesses?HCS/Health Care Research Utilization (Solved) June 26, Resource:Application of the Background and Methodology of the Research Process to Problems in.
Posts about HCS University of Phoenix Learning Team Assignment written by homeworrkaid. HCS Week 4, Evaluating the Research Process. Individual Assignment: Evaluating the Research Process • Resource: Evaluating the Research Process Grading Criteria.
HCS Week 4 Individual Assignment: Evaluating the Research ProcessResource: Evaluating the Research Process Grading Criteria.• Select one of the articles collected in the Week One Annotated Bibliography assignment.•.
This archive file includes HCS Week 4 Evaluating Research Process Health Care – General Health Care Resource: Evaluating the Research Process Grading Criteria. Select one of the articles collected in the Week One Annotated Bibliography assignment.
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Applying the Background and Methodology of the Research Process HCS/ December 22, Jonathan Hoffsuemmer Applying the Background and Methodology of the Research Process A serious problem seen by nurse practitioners that work in rural areas is teen pregnancy.
Resource: Evaluating the Research Process Grading Criteria. Select one of the articles collected in the Week One Annotated Bibliography assignment.
Write a 1, to -1,word paper that evaluates the research process within your chosen article.Download